Posted by Elizabeth on November 9, 2001, at 13:16:51
In reply to Re: DXO vs. DXM (sidetrack) » Elizabeth, posted by Cam W. on November 8, 2001, at 22:25:05
Hi John and Cam. Thanks for responding.
John:
> Have you been screened to see if you are a
poor metabollizer of cyp450-2d6 (converts the
dxm and many other meds).I'm familiar with that, and while I've never been tested for it, I probably do have that polymorphism (I'm a poor metabolizer of tricyclics).
> As far as anti-tussives go, I'll check with
my pharmacist friend and see what he recommends.I've used one called Tessalon before -- it's okay to use with MAOIs -- but it requires a script.
> ps. this is totally offbeat, but I have read
anecdotal experiences on dxm web pages suggesing not to take Corcidin branch dxm for whatever reason.People using DXM recreationally take large doses. I mean monster doses, like chugging down a whole bottle of Robitussin at once. (GROSS!) Coricidin-HBP, the kind I used, has 4 mg of chlorpheniramine, an antihistamine, in each tablet; taking a whole lot of chlorpheniramine can be dangerous.
> Do you have problems with the more standard
Robitussin-DM?Never tried it. It has extra ingredients that I don't need or want, and it offers no advantage over Robitussin-Max.
Cam:
> Elizabeth - Hmmm...so by f***ed up, what do you mean. Anticholinergic dry mouth, dizziness, visual accomodation problems; or is it "walking on cornflakes, waiting for the band to come", kinda different, headspace (if ya know what I mean; sort of a detached feeling).I don't remember having any anticholinergic side effects with it either of the first two times I took it. The third time (a few days ago), I was also taking buprenorphine, which causes pretty bad dry mouth and constipation, so it's hard to say. But I've taken chlorpheniramine by itself many times (bupe also causes severe itching) and it doesn't cause any noticeable side effects for me in doses up to 16 mg.
I'm a little bit, uh, *puzzled* by the other possible definition you gave for "f---ed up." (I don't recognize the quote, sorry.) I was very dizzy and ataxic. My thoughts were also racing in unexpected directions. I was unable to sleep. Time seemed to be passing faster some times and slower others. I tried to take my blood pressure but my pulse was too weak or something. (I have a digital BP monitor; it kept giving me "E" for "error" -- that's what it does when it can't get a reading.) Does that give you some idea? My pupils were also dilated even though I had taken buprenorphine too.
> If it's the first, it's the desipramine; if it's the second, it's the dextromethorphan.
This wasn't tricyclic toxicity.
> Desipramine can exagerrate the CNS depressants, like DM;
It really didn't feel like a CNS depressant.
> You see that detached, spacey thing when DM metabolism is inhibited by fluoxetine.
I'm not sure about detached but it was definitely spacey!
> Now, for the cough. Is it dry and hacky or productive (ie. trying to bring up mucus).
Dry, nonproductive.
> In either case, increase liquid (ie. water) intake and pee off the bug causing it, and steam to moisturize the tissues of a dry cough and to loosen the mucus of a productive cough.
Showering helps some. I always try to drink as much as I can because of the dry mouth and constipation from the bupe.
> Also, you can take straight Robitussin™ (guaifenesin) which breaks the sulphur bonds in the mucus, making it easier to cough out.
That doesn't work for dry coughs, which is why I didn't choose a product with guaifenesin in it.
> God, I hope it's a productive cough; that was a lot of typing.
Sorry dude! < g >
> As for a dry cough, you're screwed. What you can do is the liquids and steam thing. Also suck on Fisherman's Friend lozenges (orignal - white package)(Altoids can be substituted, but F.F. works better).
What's the active ingredient?
Shouldn't opioids suppress the cough reflex, whether it's dry or wet? The bupe isn't helping at all, and I'm wondering if it's because it's a partial/mixed agonist.
> P.S. John, thanks for the vote of confidence, dude (I am a community pharmacist).
I agree with him. (Hey, you said "dude." I thought I was the only person here who used that word.)
-elizabeth
poster:Elizabeth
thread:83228
URL: http://www.dr-bob.org/babble/20011104/msgs/83676.html