Posted by JGalt on November 1, 2001, at 10:05:01
On a post further up on this page "Provigil Poopout: 2 yrs better than ever", Rick posted that one of Modafinil's primary metabolization enzymes was CYP 3A4. Assuming that is the case, it may turn out that instead of using Serzone to increase modafinil's effectiveness, one could use Grapefruit Juice instead, which blocks CYP 3A4. This blockage occurs mostly in the gut, and I do not know whether mod. is metabolised in the gut or elsewhere, but it would certainly be nice if it was in this case. Personally I'd love to have a better/longer acting modafinil at the price of drinking a glass of grapefruit juice a little before taking it. Anyone have any info on whether or not Mod. is metabolized primarily in the gut or elsewhere? Xanax and many other benzo's are affected by it, as well as caffeine and bunch of other drugs, so does anyone have some research on where Mod. is metabolised? I'll get around to looking it up later if no one does, but I overspent my stay online as it is. Just as an aside, is anyone on this board taking benzo's also taking grapefruit juice and thus able to lower the benzo dosage?
JGalt
poster:JGalt
thread:82868
URL: http://www.dr-bob.org/babble/20011025/msgs/82868.html