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Re: Serzone withdrawls krista

Posted by Mitch on October 21, 2001, at 12:36:39

In reply to Serzone withdrawls, posted by krista on October 20, 2001, at 17:16:47

> I recently have been switched from Serzone to Remeron. I am tapering off the Serzone and increasing the Remeron
> I wondered if anyone else has had withdrawls coming off Serzone.
> It's hard to distinguish the difference between the withdrawls from Serzone or the side effects of the new drug Remeron. However I notice I get feeling worse
> later in the day before my Remeron dose. Therefore, that tends to make me think it is the Serzone withdrawl and not the Remeron making me feel this way.
>
> I feel spaced out, jumpy and very irritable as the day wears on. So irritable that I have actually rnan around the room wanting to hurt myself. Every time I go down more on the Serzone it gets worse. I would like to hear other people's
> experiences coming off of Serzone. Please HELP! I was on the Serzone 600 mg for about a year and a half.
>
> thanks,
> Krista

Krista,

You may be adversely reacting to the Remeron instead of withdrawal of Serzone. I have heard of reports of irritability with Remeron. It affects norepinephrine much more than Serzone (which practically does not effect NE at all). I am BPII and touchy with meds that set off irritability. It seems that anything that antagonizes the alpha-2 adrenoreceptors sets me off (Remeron and previously with Buspar). I had a pronounced irritability response to Remeron. Also, when I withdrew the Remeron I became hypomanic for a couple of days and then experienced agitation and a mild mixed episode for a few more. The Serzone may be controlling your irritability brought on by the Remeron. I would tell your doc about your irritability as soon as possible.


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