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Re: Lamictal Question Mr. Scott

Posted by SLS on October 6, 2001, at 18:53:51

In reply to Lamictal Question, posted by Mr. Scott on October 6, 2001, at 7:10:01

> Does anyone know the spproximate effective dose range for Lamictal in Bipolar, or Bipolar 2 people. At least ehere one may begin to enter the therapeutic zone?
> Also, Anyone had any GOOD experience with the drug for depression and or bipolar 2?
> Scott

Hi Scott

I read a recent publication by Robert M. Post that cited his group at the NIMH as finding 287mg +/- 150mg to be their average effective dosage. Keep in mind that his patient population is generally difficult to treat and largely treatment-resistant. I need 300mg to receive benefit from it. At 200mg, I lose it.

Yes, Lamictal can be *extremely* effective monotherapeutically to treat bipolar depression. I don't know how the rates of response differ between bipolar I and bipolar II. I don't think it would be so large as to be a determinant when reaching a decision to try it. Augmentation with lithium, Neurontin, and Depakote is effective. The dosage of Lamictal must be cut in half when Depakote is added to it.

- Scott




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