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Re: LITHIUM, as the sole AD? Chloe

Posted by Mitch on October 3, 2001, at 23:46:47

In reply to Re: LITHIUM, as the sole AD? Sunnely, posted by Chloe on October 3, 2001, at 22:06:45

> Now, I seem to be much more agitated and meds like SSRI's can zap me into a mixed or hypomanic state. I have had hypomanic reactions to a few drugs, one being Geodon (along with EPS) So, I guess treating me is more complicated now. It's also a terrible shame that I can't take the AP's, new or old anymore due to EPS and TD.
>
> One last thing, I thought this internal buzz and pulsing was from the Celexa. But I am finding it's still with me. I don't feel like I have to be moving, but it does give me an anxious feeling. Like I am "alive" inside. This is quite annoying, and I wish it would resolve. But somehow, I think it's here to stay. Will I ever feel calm and NOT depressed???

Hi Chloe,
I am in a similar situation as yourself. I have the best response with SSRI's for non-seasonal (intra-cyclical) bipolar depression and anxiety, but they exacerbate hypomania more than any other AD's. I can't take ANY (conventional or atypical)AP's due to EPS symptoms. My question is: Have you ever had a trial of an MAOI? I feel strongly that I could have a positive response to one. Tranylcypromine is indicated for bipolar depression and there is supposed to be fewer "switch" rates with MAOI's generally than SSRi's as a class. My pdoc is afraid of them and the last pdoc I had (a few years ago) was afraid of them too. Personally, I think I just saw the word "lawsuit" reading backwards in their eyeglasses. I realize the current "thinking" is "aggressive" use of mood stabilizers w/o AD's, but I am also skeptical. I have comorbid anxiety disorders that aren't helped much by without an AD. Have you had a trial of any MAOI's?

Mitch


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