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Re: Tricyclic spectrum?

Posted by Jackster on October 2, 2001, at 16:07:22

In reply to Re: Tricyclic spectrum?, posted by Mitch on October 2, 2001, at 10:10:09

> > Does anyone know of a web page that shows the spectrum of tricyclic antidepressants - i.e. what they are used for, which neurotransmitter they mainly target, and what their side effects are? For example, I know clomipramine is mainly serotonin reuptake inhibiting (and is making me really irritable) and amitriptaline is less serotonin and more of the other two (which I can't remember the names of). I've looked but can't seem to find anything that does this.
> >
> > Thanks
> > Jackie
> I came across a "transporter affinity" profile sheet once at my pdoc's. As far as TCA's go (from what I remember) the one at the top has the most affinity for the NE transporter and the ones toward the bottom increasing affinity for 5-HT transporters:
> 1) Desipramine
> 2) Nortripytline
> 3) Doxepin
> 4) Amitriptyline
> 5) Imipramine
> 6) Clomipramine
> There are a few other TCA's, but I didn't see them listed.

Thanks Mitch - that was exactly what I was looking for. And don't worry - it's not for self medicating, but so I am informed for when I see my PDoc next.





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