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Re: HOW DOES FLUANXOL WORK FOR DEPRESSION/ANXIETY?

Posted by PaulB on August 22, 2001, at 13:12:40

In reply to HOW DOES FLUANXOL WORK FOR DEPRESSION/ANXIETY?, posted by SHRINK on June 15, 2001, at 3:18:23

Flupenthixol's mechansism of antidepressant effect really isnt understood that well at all even though it has been in use as an antidpressant for thirty years now.

The best I have come up with is that it may well work via the typical monoamine hypothesis;that correcting an inbalance of serotonin, norepinephrine or dopamine will elevate mood. Flupenthixol may help do this by stimulating the release of neurotransmitters.

Although it is considered to possess a mild/moderate antidepressant effect theres no reason why it shouldnt be used to potentiate the activity of another antidpressant. It sometimes works well.

I believe the best information on it can be found at MEDLINE. I believe these may be some useful citations for anyone who is interested in further exploration of Flupenthixol as an antidepressant.

1: Lloyd-Williams M. Treatment of depression with flupenthixol in terminally ill patients. Eur J Cancer Care(Engl). 1994 Sep;3(3):133-4. PMID: 7711982[PubMed-indexed for MEDLINE]

2: Maragakis BP. A double-blind comparison of oral amitriptyline and low-dose intramuscular flupenthixol decanoate in depressive illness. Curr Med Res Opin. 1990;12(1):51-7. PMID:2188797[PubMed-indexed for MEDLINE]

3: Hamilton BA, Jones PG, Hoda AN, keane PM, Majid I, Zaidi SI. Flupenthixol and fluvoxamine in mild to moderate depression: a comparison in general practice. Pharmatherapeutica. 1989;5(5):292-7.PMID:2501801[PubMed-indexed for MEDLINE]

4: Majid I. A double-blind comparison of once-daily flupenthixol and mianserin in depressed hospital out-patients. Pharmatherapeutica. 1986;4(7):405-10. PMID: 3515368[PubMed-indexed for MEDLINE]

5: Trimble MR, Robertson MM. Flupenthixol in depression. A study of serum levels and prolactinresponse. J Affect Disord. 1983 Feb;5(1):81-9. PMID:6220047[PubMed-indexed for MEDLINE]

6: Poldinger W, Sieberns S. Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and fluepenthixol decanoate. Neuropsychobiology. 1983;10(2-3):131-6.PMID:6674820[PubMed-indexed for MEDLINE]

7: Robertson MM, Trimble MR. the antidepressant action of flupenthixol. Practioner. 1981 May; 225(1355):761-3. No abstract available. PMID: 7291129[PubMed-indexed for MEDLINE]

8: Conway JF. Flupenthixol versus combined flupheazine-nortriptyline in depressive illness. practioner. 1981 Mar;225(1353):400-4. No abstract available. PMID: 7022433[PubMed-indexed for MEDLINE]

9: Kielholz P, Terzani S, Poldinger W. The long-term treatment of periodical and cyclic depressions with flupenthixol decanoate. Int pharmacopsychiatry. 1979;14(6):305-9. PMID:548504[PubMed-indexed for MEDLINE]

10: Fujiwara J, Ishino H, Baba O, Hanaoka M, Sasaki K. Effect of flupenthixol on depression with special reference to combination use with tricyclic antidepressants. An uncontrolled pilot study with 45 patients. Acta Psychiatr Scand. 1976 Aug;54(2):99-105. PMID:961463[PubMed-indexed for MEDLINE]

11: Young JP, Hughes WC, Lader MH. A controlled comparison of flupenthixol and amitriptyline in depressed outpatients. Br Med J. 1976 May 8;1(6018):1116-8. PMID:773506[PubMed-indexed for MEDLINE]

12: Nistico G, Marano V, Scapagnini U. Flupenthixol in depression. Acta Neurol (Napoli). 1975 Jan-Feb;30(1):102-8. No abstract available. PMID: 1225021[PubMed-indexed for MEDLINE]

13: Frolund F. Treatment of depression in general practice: a controlled trial of flupenthixol('Fluanxol'. Curr med Res Opin. 1974;2(2):78-89. No abstract available. PMID: 4597572[PubMed-indexed for MEDLINE]

14: Hall P, Coleman J. Flupenthixol in the treatment of depressive states. Br J Psychiatry. 1973 Jan;122(566):120-1. No abstract available. PMID: 4683016[pubMed-indexed for MEDLINE]

15: Sonne LM. [Depressive conditions treated with flupenthixol]. Nord Psykiatr Tidsskr. 1971;25(5):454-62.
Swedish. No abstract available. PMID: 5144304[PubMed-indexed for MEDLINE]

16: Sonne LM. [The treatment of depressive states with folupenthixol]. Nord psykiatr Tidsskr. 1966;20(4):322-4. Danish. No abstract available. PMID: 5341429[PubMed-indexed for MEDLINE]


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