Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: COLETTE/others: ZYPREXA + Weight gain: » cb

Posted by Cam W. on August 22, 2001, at 9:25:58

In reply to Re: COLETTE/others: ZYPREXA + Weight gain:, posted by cb on August 22, 2001, at 9:06:54

Janelle - Actually, the Axid™ (nizatidine) is supposed to be taken at the start of Zyprexa™ (olanzapine) therapy, and is supposed to prevent the weight gain caused by the Zyprexa. We have had several people try it and have not had any success. Still, approximately 70% of people taking the Zyprexa (with or without taking Axid) gain weight.

A few years ago, on this site, Dr.Stephen Stahl (editor of The Journal of Clinical Psychiatry) was misquoted as saying he backed the use of H2-antagonists (like Axid, Zantac, Tagamet, etc.) for mirtazapine weight gain. Stahl sent a note to Dr.Bob stating that he did not think that H2-antagonists would prevent weight gain.

I have been hearing the H2-antagonist for the prevention of weight gain story for a couple of years now. It came out of the Eli Lilly head office in the U.S. and first pertained to Tagamet™ (cimetidine). I corralled the speaker who said it, after the presentation, and asked where he got his information. He said that he got it from Eli Lilly. When I asked about a possible mechanism of action, he said that cimetidine was a very "dirty" drug ie. attaches to many different receptors) and it was probably not the involvement H2-receptor.

I know of several psychiatrists who have tried cimetidine, ranitidine (Zantac™) and nizatidine (Axid™) with no more than the 30% of Zyprexa consumers not gaining weight (and they wouldn't have gained weight, anyway).

BTW - Axid is also made by Eli Lilly. - Cam


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Cam W. thread:75857
URL: http://www.dr-bob.org/babble/20010822/msgs/75921.html