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Re:Interesting question-Anyone know?????? SHRINK

Posted by shelliR on August 7, 2001, at 23:36:46

In reply to Re:Interesting question-Anyone know??????, posted by SHRINK on June 16, 2001, at 4:45:10

> Dear Paul,
>
> I'm glad someone else shares my curiosity (or is it *right to know*?). I've got hold of the manufacturers (Lundbeck) and asked them for information re: the mechanism of flupenthixol in depression/anxiety. Let's hope they know!? I'll post any answers I get out of them. I've got quite a few patients who are using it with great effect but I feel uncomfortable recommending medications when I don't adequately understand their mechanism of action. The same goes for low dose sulpiride (Dogmatil).

Well, I do think it is important to know that the longer you take it, the greater risk there is of TD. So, it does seem like a problem if the "withdrawal" symptoms are that great. I just terminated with a pdoc for a variety of reasons, among them her insistance on me using an atypical AP for depression without statistical information available concerning TD . Most companies release relative comparisons in their summaries, without including any data, i.e. TD is much less likely to occur with the newer APs than the older. I believe if the stats were that good, they would be releasing them; some of these drugs have been on the market for ten years.

I would not want a pdoc to prescribe them for depression unless that was the only possiblity left. I can't believe that pdocs prescribe them for sleep; it flips me out when there are so many other safter drugs for sleep. So, even though we don't yet *know* the exact mechanisms of how APs work, we can compare efficacy, as well as safety.

Shelli


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