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Re: wow thanks for the info can we die? » Sunnely

Posted by gldngodess on August 1, 2001, at 21:59:03

In reply to Re: Bruising on Celexa, anyone? » KB, posted by Sunnely on August 1, 2001, at 20:58:53

> Easy bruising has been reported with the use of SSRIs (e.g., Prozac, Paxil, Zoloft, Celexa, Luvox) and Effexor (a serotonin and norepinephrine reuptake inhibitor). This adverse reaction appears to be more common with Prozac. Other bleeding tendencies reported with the use of serotonin-reuptake inhibitors (SRIs) include nose bleeding (epistaxis), menorrhargia (heavy menstrual flow) and other menstrual problems, ulcerations with hemorrhage, bleeding internal hemorrhoids, and melena (blackish stool).
>
> The mechanism as to how this adverse reaction occurs seems related to the effect of the SRIs on serotonin. Under normal circumstances, platelets (blood particles responsible for clotting) release serotonin at the site of vascular tears, leading to further platelet aggregation and vasodilation (blood vessels enlarge). This permits sealing of the tear stopping the bleeding. It appears that the SRIs block the reuptake of serotonin into the platelets which lead to decreased serotonin to be released by the platelets into the site of bleeding.
>
> Concomitant drugs or herbs taken along with the SRIs may also increased risk of bleeding tendencies. For example NSAIDs (nonsteroidal anti-inflammatory drugs such as Motrin, Aleve, etc., and aspirin), which have anti-platelet effect, taken with SRIs may increase one's risk for gastrointestinal bleeding. Herbs like ginseng, garlic, guarana, ginger, and ginkgo (the "G" herbs) taken along with SRIs may also increase the risk for bleeding tendencies.
>
> The following is also theoretically possible. When someone on SRIs consumes more green, leafy vegetables (abundant in the summer months), the risk of bleeding may also increase. Vitamin K is found in these vegetables and excesssive consumption along with SRIs may further increase risk for bleeding.
>
> The following is a case of spontaneous bruising reported with the use of Effexor. A 19-year-old woman developed spontaneous bruising on her arms a week after beginning Effexor, 50 mg twice a day. She had no personal or family history of any bleeding disorder nor any other medical condition. Her clotting factors and platelet count were noted to be within normal limits. Once Effexor was stopped, her bruisings resolved over 10 days.
>
> ***********************
>
Can we die from this? Please tell me? Like if I have surgery?


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poster:gldngodess thread:3948
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