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Re: What's the difference btwn remeron and serzone? » MM

Posted by SalArmy4me on July 20, 2001, at 0:52:47

In reply to What's the difference btwn remeron and serzone?, posted by MM on July 20, 2001, at 0:13:33

Comparison to of Remeron to Serzone:

1. Remeron is more convienient than Serzone because its taken once at bedtime (Serzone is taken BID).

2. Remeron has the potential for increase of libido due to its blockade of the alpha-2 NE receptor, unlike Serzone.

3. Remeron might provide relief from Serzone's nausea due to the blockade of the 5HT-2C receptor.

4. Remeron can be started at a therapeutic dose, unlike Serzone which requires titration for toleration (http://www.preskorn.com/cgi-bin/sp.pl?words=doxepin&wt=be&bl=an&d=/books/omd_s8.html)

5. The risk of pharmacokinetically mediated drug-drug interactions is higher with Serzone due to the inhibition of the drug metabolizing CYP 3A3/4 enzyme; nefazodone has the potential to cause CYP enzyme-mediated drug-drug interactions like fluoxetine, fluvoxamine, and paroxetine. Nefazodone-induced inhibition of CYP 3A3/4 can elevate levels of coprescribed drugs dependent on this CYP enzyme for their oxidative metabolism and that, in turn, can cause untoward consequences: http://www.preskorn.com/columns/9803.html

> I didn't take well to SSRI's, but serzone was the best out of the bad I guess. Would remeron be basically the same?


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