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Benzodiazepine Tolerance

Posted by PaulB on June 28, 2001, at 17:26:19

PaulB wrote:

I wanted to find out about the causes of the tolerance that can occur when exposure to a benzodiazepine is given for longer period of time. Going back to basics, benzodiazepines exert their anxiolytic, amnesic, muscle-relaxant, hypnotic and sedative effects by binding to the omega receptors and thus potentiating the brain natural supply of GABA. Can anyone tell me whether the tolerance that may occur with longer term exposure to these drugs is caused by a decrease in the sesitivity and/or no of bz omega reptors or lowered levels of the brain own supply of natural GABA that the benzodiazepines potentiate.

I would appreciate to hear from all those people who have experience and knowledge of this type of psych-babble and look forward to seeing the responses I get
Take care
PaulB


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poster:PaulB thread:68279
URL: http://www.dr-bob.org/babble/20010625/msgs/68279.html