Posted by Mitch on June 18, 2001, at 23:22:31
In reply to Re: Any success with Provigil (Modafinil) for ADHD? » Mitch, posted by SalArmy4me on June 18, 2001, at 12:27:30
> RUGINO, THOMAS A. M.D.. COPLEY, TERESA C. M.S.. Effects of Modafinil in Children With Attention-Deficit/Hyperactivity Disorder: An Open-Label Study. Journal of the American Academy of Child & Adolescent Psychiatry. 40(2):230-235, Feb 2001:
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> "Modafinil was administered once a day in the morning to 15 children, 11 (73%) of whom completed the study. Treatment with modafinil resulted in statistically significant improvements in clinical parameters that are commonly used to follow the progress of treatment of children with ADHD. In this study, the positive effect is more pronounced for hyperactive-impulsive features (TOVA impulsivity subscore, p = .006) compared with the inattentive features (TOVA inattention subscore, p = .086).
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> Modafinil demonstrated an effect duration that lasted past the end of the school day for all but 1 of the 11 subjects who completed the study, suggesting that once-per-day dosing was adequate for maintenance of school-based activities. Adverse events were minor and manageable without medication discontinuance in four of the five children with side effects. The most common adverse event was delayed onset of sleep or sleep disruption which, in two of the three cases, responded favorably to a reduction of dose. This compares well with the rate of adverse events from other stimulants used for management of ADHD (Fox and Reider, 1993). Specifically, methylphenidate and amphetamines are commonly associated with weight loss and appetite suppression during the early course of administration (Klein et al., 1988; Schachar et al., 1997; Schertz et al., 1996). In contrast, no patients given modafinil as part of this study lost weight or experienced decreased appetite..."thanks Sal,
Mitch
poster:Mitch
thread:66963
URL: http://www.dr-bob.org/babble/20010618/msgs/67023.html