Posted by Elizabeth on June 3, 2001, at 21:03:53
In reply to Re: Motivation ?!, posted by JohnL on June 1, 2001, at 14:46:19
> For hypo-motivational symptoms I think the best meds are the ones that focus on norepinephrine and/or dopamine D2.
My experience has been that the opioids are the most effective drugs for this. This is pretty weird since they have the opposite reputation. It also sucks because they have very heavy side effects. I'd much rather be on stimulants or antidepressants.
> For me what has worked incredibly well is the combination of Adrafinil and Zyprexa, both at minimum doses, with a little Prozac in the background. These three meds, in my opinion, should be put at the top of the list before anything else.
That's surprising (perhaps even more surprising than my reaction to opioid agonists). Antipsychotics tend to be anti-motivational for most people. My response to Moban (which I think I've discussed elsewhere, although it's hard to describe) was an extreme example of this (I experienced the other antipsychotics I've taken as merely sedating).
Amisulpride is an exception because of its differing effects at high vs. low doses.
Also, many people suffer an amotivational syndrome after long-term use of SSRIs. I wouldn't necessarily recommend these, either.
-elizabeth
poster:Elizabeth
thread:64725
URL: http://www.dr-bob.org/babble/20010530/msgs/65294.html