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Re: antiglucocorticoids in depression - confusing

Posted by SLS on May 31, 2001, at 19:03:45

In reply to Re: antiglucocorticoids in depression, posted by SLS on May 31, 2001, at 18:40:38

Specifically, I am a non-suppressor to dexamethasone challenge.

> If it helps to add to the database, I consistently test positive for the dexamethasone suppression test (DST). Unfortunately, I don't recall ever having been tested for baseline cortisol, although I am sure the NIMH assayed for it. I certainly gave them enough blood for them to have been able to. I have bipolar disorder that presents as an uanremitting chronic severe anergic depression with reverse vegetative symptomology and social anxiety / inhibition. Although bipolar depression is sometimes likened to atypical unipolar depression, the most important difference (for me, anyway) is the lack of mood reactivity.
> Good topic. Cam W. should speak up. He has done quite a bit of reading on this issue and I believe has spoken to Dr. C. Nemeroff, a researcher who has focused on HPA CRH-cortisol stuff.
> - Scott




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