Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Trazadone and Effexor combo?????? » DebbieLynn

Posted by Cam W. on May 27, 2001, at 11:32:29

In reply to Trazadone and Effexor combo??????, posted by DebbieLynn on May 27, 2001, at 10:33:13

Debbie - There is usually no problem taking a serotonergic antidepressant like Effexor XR™ (venlafaxine) with a low dose of trazodone (Desyrel™). The problem of serotonin syndrome can occur (and then, not always) when you increase the trazodone to a dose where it's antidepressant activity kicks in (ie. 450mg to 600mg). Trazodone is not used much as an antidepressant anymore because it is far too sedating. The serotonin syndrome is definitely dose related. I have seen a mild case of serotonin syndrome in someone who was taking Paxil™ (paroxetine) at a 10mg daily dose and 100mg of trazodone at bedtime. When we lowered the trazodone to 25mg, the symptoms of serotonin syndrome went away.

Trazodone, in doses of 50mg to 100mg at bedtimes, are common used as a hypnotic in people taking SSRIs and other serotonergic antidepressants (except classical MAOIs, where the risk of serotonin syndrome is much greater). Trazodone is one of the safest sleeping pills for seniors, as well. I would try to avoid taking the 300mg dose very often, as it will affect your daytime performance because of the hangover effect your doc mentioned.

I hope that this is of some help. - Cam




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Cam W. thread:64412