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Re: ssri to Lamictal? chloe

Posted by JahL on May 22, 2001, at 19:13:22

In reply to ssri to Lamictal?, posted by chloe on May 22, 2001, at 18:53:02

> Can lamictal be used as an AD for unipolar depression?

Rarely is, but yes.

> I don't think I am bipolar, but when I go on an SSRI, like prozac, zoloft, and now celexa, I get so revved up and pressured, irritable

Me too. Become hostile. According to my oh-so-knowledgable pdoc it is 'pharmacologically (big word for him) impossible' for this reaction to occur. Guess we know different, huh?

> I get alot of relief from anger and mood swings with the mood stabilizers.

Me too.

>But they never seem to address my depression.


> But when I add an AD I tend to get the hypomania thing.

Me too; euthymia (briefly) also. I've been dx'd unipolar but I'm *certain* I'm Bipolar III (if you accept this nebulous classification) due to having some of the reactions you describe & more.

> Does anyone know how Lamictal works as an AD? Does it work on Seratonin, or some other pathway? Any info would be appreciated. I really hate the edgy, rushed feeling I always have on these AD. But I do something to keep the negative thoughts away.

No idea how it works but wld be interested to know. Not sure anyone is clear on its precise mode of action.

fwiw, I'm taking Lamictal 350mg. Removes suicidal ideation, as with all mood-stabilizers, & has the added bonus of discernably improving cognition (others report this). Doesn't touch depression tho'. That said *some* report excellent results from Lamictal monotherapy (I've just added Gabapentin to little effect).

Good luck,




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