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Re: NAUSEA !!! Please help !!!

Posted by ben on May 19, 2001, at 8:56:17

In reply to Re: NAUSEA !!! Please help !!! » ben, posted by Cam W. on May 18, 2001, at 18:21:47

> Ben - Sorry not respond earlier but I haven't been reading all the posts lately, to stay out of the latest kurfuffle.
> Anyway, what is probably happening to you is, is that your body is readjusting to life without artificially raised serotonin levels. In your case, the nausea you feel may be caused by serotonin-3 (5-HT3) receptors in your gastrointestinal tract. The stimulation of 5-HT3 receptors by serotonin when you start SSRIs causes the initial start up side effects of nausea. The reverse may be happening to you. Now that the 5-HT3 receptors aren't being stimulated as much (because of the withdrawl of the SSRI Celexa™ - citalopram) they have probably rebounded in number and concentration in your gut or have become hypersensitive. This should begin to dissipate in a week or two and should be totally gone by the end or 3 or 4 weeks.
> I do have one concern with your cases, and please, anyone, tell me if I am out in left field with this. You may have to watch for a return of depressive symptoms over the next 6 months. The overstimulation of the 5-HT3 receptors (if indeed, that is what is happening) makes me think that you were either tapered to fast from the Celexa or your body isn't producing enough serotonin on its own. If either of these are true, it would mean that your body is not readjusting to the lower levels of serotonin. If the body doesn't catch up and produce more serotonin, then you may be at risk for another depressive episode. This is only a hunch and you should probably monitor your moods for the next few months. Like I say, I could be wrong on this, but I have seen a similar case result in a relapse.
> Also, flat, sugared ginger ale (ie stir the bubbles out & the sugarfree one doesn't seem to work as well). Also, you can suck peppermints or drink peppermint tea or ginger tea. You could also try ginger capsules. These are probably the safest remedies for nausea.
> Hope this helps - Cam
Hi Cam, I still have depressive symptoms ! I had to give up the celexa because it didnt give me a remission after one year of use. So my doc wanted to change my medication. Since then it worsened. I am very sensitive to side effects, so the celexa was at first a good decision. I had a good response to Effexor, but I gained weight, headache and dust in the brain. Lithium failed because I had awful nausea and Surmontil (Trimipramine) made me to sedated. And all of them hadndt reliefed all my symptoms.




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