Posted by SalArmy4me on May 16, 2001, at 13:09:06
In reply to Re: Anyone had success on Effexor XR? , posted by wen on May 16, 2001, at 12:40:46
Dry Mouth: This effect is most commonly seen with antidepressants that block the muscarinic acetylcholine receptor, but may also occur with norepinephrine uptake inhibitors (like Effexor). While it is frequently considered a trivial adverse effect, it can result in increased tooth decay and gum disease due to the loss of the bacteria-fighting effects of saliva. You should practice excellent dental hygiene, including brushing after every meal, avoiding snacks (particularly those which are sweet), and flossing. Chewing sugarless gum can be helpful.
For the sleeplessness, you may want to move your dose to earlier in the day.
Here's what Dr. Preskorn says about the dizziness:
"The dizziness caused by 5-HT1A stimulation is most likely centrally mediated. It can occur early in treatment with antidepressants which inhibit serotonin uptake (eg, SSRIs and Effexor)... There are no cardiovascular changes associated with it. Balance and coordination are subjectively, but not objectively, affected. **Tolerance commonly develops within days to a week..."
I agree with the Dr. that tolerance does develop to some Effexor symptoms.