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Re: when ssri's stop working, what's next?

Posted by jb on March 29, 2001, at 18:10:14

In reply to when ssri's stop working, what's next?, posted by izzy on March 29, 2001, at 17:22:20

Hi. You have lots of alternatives. First, the SSRI's inhibit serotonin reuptake, thereby making more serotonin available for message transmission. Serzone, alternatively, does not inhibit reuptake, but antagonizes or blocks a serotonin receptor post-synapse. Essentially, an alternative to achieving the same end goal. Wellbutrin also is different from the SSRI's, as are some other meds. The MAOI's, work through a different mechanism, and I find their dietary restrictions to be somewhat overblown. Parnate, an MAOI, is somewhat stimulating, and caused me to lose about 10 pounds. Also, both Serzone and Wellbutrin are supposed to be without weight gain effects.

Alternatively, your psychdoc, who, I hope, is well versed in pharmacology, could tried augmentation and combination therapies, to give you a more robust response.

Please discuss it with your psychdoc. By the way, in general, I find the most informed and least cautious psychdocs are with university based psychiatric programs. You may want to go to the nearest one for a consult.

Best of luck.

JB


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poster:jb thread:57982
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