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Re: Please help! latest... adrafinil trial JohnL

Posted by JonW on March 11, 2001, at 18:46:28

In reply to Re: Please help! latest... adrafinil trial, posted by JohnL on March 10, 2001, at 5:26:58

Thanks for taking the time to respond, and all the good advice! I agree that dopamine has been somewhat overlooked, and my intuition as unscientific as it may be tells me dopamine is an important player in my problems. It's my understanding that the drugs you suggested lower dopamine. Why not try drugs that raise dopamine? I've read Dr. Jensen's book and I don't seem to have much in common with those who typically suffer from dopamine elevation, but I do believe that any chemical imbalance can cause any problem. I'm concerned about lowering dopamine and sexual dysfunction. Would zyprexa + bromocriptine cancel each other out? I recently stopped adrafinil due to a significant elevation of blood pressure, but I may give it a go again at a later time. I tried lithium alone today and it made me very depressed and I startled more easily than usual. Klonopin seemed to remedy the situation somewhat. I'm curious if this reaction to lithium is an important piece of information? Thanks again for all your help! The world would be better off if there were more people like you! Or at the very least, if my doctor was more like you :)


> Hi Jon,
> You provided very good information. The one thing that popped out at me was 'dopamine'. Though some of the drugs you've tried had slight effects on dopamine, none of them really focus on that. I think that is the one area that has been overlooked.
> Specifically I think you would do well to stay with the Adrafinil for at least 4 weeks. Take an OTC pain reliever as needed until the headaches go away. They are likely caused by increased noradrenaline function, which will adjust and go away. But in addition, I think you might do well to steer your direction toward dopamine drugs. I'm thinking of drugs like Zyprexa, Amisulpride, Risperdal, in that order. Any of them can be added to Adrafinil. Zyprexa in particular will cure any insomnia, and any sedation will not carry over into the next day after you adjust to it. For me that was about a week.
> I'm pretty confident you may find one of those drugs helpful. They've helped a lot of difficult cases here in babbleland, including me. Small dose (5mg to 10mg) Prozac may also be very helpful. It goes very well with the other drugs I mentioned. At that dose there shouldn't be any sexual side effects. I take 20mg with no side effects. (Paxil and all the others had terrible sexual side effects for me.)
> Hope something here is helpful.
> John




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