Posted by JohnX on March 9, 2001, at 2:57:28
In reply to Thanks John X, posted by JohnM on March 7, 2001, at 16:17:14
> Sure, I wouldn't mind you looking it up for me (the grapefruit juice trick) ha ha! Any information would be useful!
>
> I take a small dose of Nardil at present. I've tried almost all the SSRI's and they didn't work for me (made me agitated/anxious). Thanks for your input. JohnWell I've looked at Xanax, and from the PDR and studies the best way to increase the 1/2 life is to take it with Luvox, which you can't do with the Nardil. Other meds like Serzone and some anti-biotics increase the plasma concentrations but have less effects on the 1/2 life meaning you could get the same effect of Xanax at a lower dose, but it still would crap out in the same amount of time.
The clearance of most of those benzos occurs within the CYP 3A group of enzymes in the liver.
Here is a good table that shows how various meds work on certain liver enzymes.:
http://www.georgetown.edu/departments/pharmacology/davetab.html
Generally if med A uses substrate X and med B inhibits substrate X, then the clearance of med A is reduced. If med B induces substrate X, then the clearance is increased. Are you taking any of the substances listed under the 3a4,5,7 inducer table?
I haven't checked on Nardil's metabolism.
If you can find the PDR for a med by going to the manufacturers web page it should list how the drug is metabolized (which enzymes are involved) and what the major interactions are with other meds.
-John
poster:JohnX
thread:55579
URL: http://www.dr-bob.org/babble/20010302/msgs/55982.html