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Re: Prozac Zyprexa Study

Posted by JohnL on March 6, 2001, at 5:16:12

In reply to Re: Prozac Zyprexa Study » Neal, posted by JohnX on March 6, 2001, at 2:49:42

> > A Vanderbilt study has found that Prozac and the antipsychotic Zyprexa work better together on treatment-resistant depression patients than either drug alone. Twenty-eight patients were given either Prozac and a placebo, Zyprexa and a placebo, or the two drugs together. After eight weeks, researchers found a "minimal" improvement with Prozac, a "modest" improvement with Zyprexa, and a "significant" improvement with the combination.
>
I have always felt that Prozac+Zyprexa is a great combination. Not sure why. There just seems to be some synergy with them that turns out to be very helpful for a whole wide range of symptoms, especially for people who have had less than adequate results with straight forward antidepressant therapy.

Prozac+Zyprexa dramatically raises levels of serotonin, norepinephrine, and dopamine. Zoloft+Zyprexa raised only dopamine. Risperdal+Prozac also raised neuro levels, but not as impressively or as efficiently as Prozac+Zyprexa.

The two drugs tend to have counteracting side effects which is an added bonus. While Prozac generally causes side effects of insomnia and/or anxiety, Zyprexa counters both of those, allowing for good sleep and reduced anxiety. Weight loss is common with Prozac while weight gain is common with Zyprexa. They help to cancel each other out. Not for everyone of course. Mileage varies. But generally speaking.

Either Prozac or Zyprexa alone can be ok. But when results are just ok, the combination can remarkably improve results. It's almost as if the sum is greater than the two parts.
John


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