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Re: depakote and wellbutrin and weight gain????

Posted by AndrewB on February 23, 2001, at 0:22:48

In reply to depakote and wellbutrin and weight gain????, posted by bonni on February 21, 2001, at 15:34:04

> i am on 100 mg. of wellbutrin SR a day and i have had NO appetite and have been losing weight. my doctor just added 500 mg. of depakote ER and says it will make me gain weight and i am not happy about that. has anyone had experience with this? maybe the wellbutrin will counteract the depakote or something? any tips????

Depakote can cause weight gain and sedation, fatigue and malaise. Depakote causes can cause carnitine deficiency and this is thought to cause the sleepiness, fatigue and malaise. People on Depakote often get there blood levels checked and find that the carnitine levels are low. When carnitine is then added to their diet there is often a dramatic improvemnet of these symptoms. Carnitine has been proposed to also combat Depakote weight gain but there are no studies on this.

Dosage is 500-1000mg. twice a day. It is important to buy l-carnitine as the d-carnitinemay be harmful. L-carnitine can be purchased in health food stores. Since healthfood supplements are not strictly regulated by the government, there is a the chance that what you buy may not be pure l-carnitine (i.e. may contain d-carnitine). Ask a knowledgeable attendant at a healthfood store what brand(s) are known to have high standards of purity. The safest bet for pure l-carnitine is to get Carnitor, l-carnitine that is available only by a doctor's prescription.

AndrewB


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