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Re: Lamictal dosing (and fibromyalgia)

Posted by SLS on February 19, 2001, at 8:10:43

In reply to Re: Lamictal dosing (and fibromyalgia), posted by SalArmy4me on February 19, 2001, at 6:00:39

Dear SalArmy4me,

> You have very little to fear about Lamictal rashes.
> The fears over Lamictal (lamotrigine) rashes are unfounded.

> The chance of having a severe rash leading to hospitalization is reported as 0.3%. With those odds, it is easier to get hit by
lightening than it is to have a Lamictal rash. Point in case: You never hear in the paper about someone severely harmed by Lamictal.

Could you please cite the published facts that lead you to your conclusion? Is it something that I can find on the internet? It is very possible that such a low incidence of hospitalization and fatality (0.3%?) due to Lamictal-induced rash is because DOCTORS ARE SMART ENOUGH TO DISCONTINUE THE DRUG BEFORE IT GETS THAT FAR!

In the meantime, I wouldn't coax mother nature to fight a battle of wits, with either Lamictal or lightning. I wouldn't encourage making such rash judgments. :-) (dumb, I know)

By the same token, I find Lamictal to be very effective and without many cognitive side effects - perhaps the lowest of the anticonvulsants. I would not hesitate to recommend it to anyone so long as they follow the prescribed schedule of dosage titration.


Schedule of Lamictal (lamotrigine) dosing for depression when not combined with any other anticonvulsant-type mood-stabilizer:

weeks 1-2 - > 25mg
weeks 3-4 - > 50mg
weeks 5 - > 100mg
thereafter + 50mg every one to two weeks.


This schedule somewhat conservative, but is still more rapid than many doctors are willing to use for certain individuals. If one develops a rash with Lamictal during an attempt at a very rapid titration, the drug can be discontinued and successfully restarted using a more conservative schedule.

Good luck all...

- Scott




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