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Mirapex will be the next Remeron of ADs

Posted by SalArmy4me on February 13, 2001, at 4:05:11

First, the background: I have treatment-resistant depression with painful flashbacks and Obsessive-Compulsive Disorder.

Mirapex started working for me in a little less than a week (possibly because I got up to 6 mg per day in two days' time)!  I found out that it needs to be taken about every 5 hours, otherwise I relapse.  I have no side-effects from it (thank God).

Mirapex is a dopamine agonist that is most often used for Parkinson's Disease.  But, it has been shown in two studies to have antidepressant properties in non-Parkinson's patients.

Studies on Medline:
2. Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review Ann Clin Psychiatry. 2000 Sep;12(3):137-40. [Record as supplied by publisher] PMID: 10984002
3:
Maj J, Rogoz Z.
Related Articles
Synergistic effect of pramipexole and sertraline in the forced swimming test. Pol J Pharmacol. 1999 Nov-Dec;51(6):471-5.
PMID: 10817524
4: Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Related Articles Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000;11(2):58-65. PMID: 10812530
5: DeBattista C, Solvason HB, Breen JA, Schatzberg AF. Related Articles Pramipexole augmentation of a selective serotonin reuptake inhibitor in the treatment of depression. J Clin Psychopharmacol. 2000 Apr;20(2):274-5. No abstract available. PMID: 10770475
6:
Goldberg JF, Frye MA, Dunn RT.
Related Articles
Pramipexole in refractory bipolar depression.
Am J Psychiatry. 1999 May;156(5):798. No abstract available.
PMID: 10327923
7:
Bennett JP, Piercey MF.
Related Articles
Pramipexole--a new dopamine agonist for the treatment of Parkinson's disease. J Neurol Sci. 1999 Feb 1;163(1):25-31. Review.
PMID: 10223406
8: Piercey MF. Related Articles Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease. Clin Neuropharmacol. 1998 May-Jun;21(3):141-51. Review. PMID: 9617505
9:
Willner P.
Related Articles
The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14. Review.
PMID: 9347387


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poster:SalArmy4me thread:53858
URL: http://www.dr-bob.org/babble/20010212/msgs/53858.html