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Re: Sulpiride, Tardive Dyskinesia and Me

Posted by AndrewB on February 13, 2001, at 3:15:44

In reply to Sulpiride, Tardive Dyskinesia and Me, posted by jimmygold70 on February 12, 2001, at 18:29:17

Jimmy,

Neuroleptics commonly cause TD with long range use at high doses and can on occassion cause it at low doses. Sulpiride and amiuslpride are both known to cause much less and incidence of extrapyramidal symptoms than older neuroleptics in high doses. My impression is that TD is also not very common when they are used in high doses. I haven't heard of any cases of TD being caused by low doses of sulpiride or its cousin amisulpride. I've used amisulpride for over a year and a half without side effects. It is common for p-docs to lump the side effects of high dose neuroleptics such as sulpiride with the low dose use of them. This doesn't make since though because low dose neuroleptics like sulpiride work in what can most simply be described as in an physiological opposite manner of the high doses. Whereas the high doses are blocking a receptor that can thus cause TD, low doses are actually (indirectly) stimulating them.

Glad the sulpiride helps. Don't be afraid to try a higher dose.

Anyway- if it eases your mind- Memantine, an NMDA agonist, prevents neuroleptic TD. You can add it on if necessary. It is safe and without side effects.

AndrewB



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URL: http://www.dr-bob.org/babble/20010212/msgs/53856.html