Posted by JohnX on February 12, 2001, at 1:48:02
In reply to Re: Adderall tolerance , dosing, etc. » JohnX, posted by Sulpicia on February 11, 2001, at 18:15:44
> > I'm curious what sort of sensitization (poop-out)
> > issues other people on this group have had
> > with Adderall.
> > I've taken it twice as a last ditch effort to
> > treat depression.
> > The 1st time I took it standalone and it it would
> > poop out after about every 3 days.
> > I took it once a day in the morning with a
> > mean dose of ~20 mg. I would always seem to get
> > erratic responses. One day 10mg drove me frantic.
> > Another day 30 mg did nothing.
> In my experience this is an extremely unusual situation.
> Can you be more specific about what you mean by "poop out?"
> Do you mean that you became depressed again or where no longer experiencing the euphoria
> that can accompany the initial doses of adderall?
> Is depression an ironclad diagnosis? Can you correlate
> what you ate with the days on which the adderall didn't work?
> There are some food interactions.
> I take adderall 40 mgs [20am,10,10] for ADD; also dx depression
> for 4th time so I took paxil 30 mgs -- the paxil potentiated the effect
> of the adderall. I hated what paxil did to my muscles [I run, or I used to!]
> so I'm switching to old friend tofranil, which dampens the adderall.
> In general, people with ADD tend not to develop a tolerance -- god knows why.
> 3 days must be some kind of record but I have to admit I have come
> across several people who didn't respond to adderall at all.
> > Curiously, I tried Adderall again with Klonopin
> > to reduce fatigue.
> Are you only on a benzo for depression?????
> This time I always got the
> > same Adderall response at 20mg. I found this strange
> > and actually found an abstract describing how
> > clonazepam (Klonopin) could prevent amphetamine
> > sensitization. Unfortunately I got poop-out on Klonopin,
> > another addictive med, and everything went to *ell.
> Sorry -- sounds like you were very nearly pulled in twain here.
> > I have looked at the addiction pathway of amphetamine,
> > and their is a simple and interesting medication in
> > the pipeline which may prevent tolerance issues,
> > without addiction to the additive medication.
> > (Another guru in this NG is studying it).
> That should be interesting, especially since the problem
> with amphetamine is that simultaneously blocks dopamine reuptake
> and increases the levels by shoving more of it out of the
> little storage pockets in the neuron -- god I hope I'm remembering
> correctly! Please forgive my flubs. It would be a neat trick
> to alter secretion and blockage w/out problems.
> > Anyones comments on Adderall dosing issues welcomed.
> > I'm very curious if my sensitization is much
> > greater than the average joe's.
> You react very strangely to this med -- and believe me,
> I've heard a few! The only thing that can be deduced
> here is that the meds were expired, you ate something
> that inactivated it, or your system doesn't tolerate it
> very well.
> Have you tried dexedrine or could you try adderall as
> an add-on with an appropriate SSRI?
> I wonder about 10 mgs making you frantic; I imagine you've
> tried mood stabilizers for depression like lamictal? Or lamictal
> in combo with an SSRI?
> Sorry not to be of more help. I do hope you find something that
> works for you.
Thanks for your comments.
By poop-out, I mean the med does nothing,
like taking a placebo.
I've been on all the anti-depressants and
I tend to get very "bizarre" responses that my
doctors don't understand. If the med works I quickly
switch into a mild mania and then a variable
time will pass before my emotions go completely
numb and I get excruciating pain in my face.
After a while the facial pain also accompanied
tingling in the extremeties and restless legs
syndrome. The Klonopin cured the pain syndromes
and helped to stabilize my mood (i've since switched
to lamictal because of addiction).
I am probably going to go down the path of:
anti-convulsant + antidepressant
anti-convulsant + aderrall
When I took Klonopin and Adderall I felt like
a human being for many months until Klonopin
died on me. And the Adderall always gave the
same response at 20mg. I've been trying to understand
if there is any correlation to my Aderrall trials
and my anti-depressant trials.