Posted by SLS on February 9, 2001, at 14:14:35
In reply to Re: Ondansetron for depression, posted by PhoenixGirl on February 9, 2001, at 10:08:08
Ondansetron does antagonize (block) a specific serotonin receptor that is different from any of the antidepressants or neuroleptic antipsychotics. While these latter drugs antagonize 5-HT2a receptors, ondansetran antagonizes 5-HT3 receptors. Reducing the activity of these serotonin neurons sometimes helps to relieve nausea and vomiting, particularly after surgery.
> I don't know about modafinil. In my pill book, it says that people taking modafinil may get high. Also I read a study in which modafinil was found to be an effecting AD augmenting agent.
> I know less about odansetron. I know that it is a serotonin antagonist, like a lot of antipsychotics, and antipsychotics can sometimes augment ADs.
> > It has a section in it about new possible antidepressants. Odansetron, adrafinil, modafinil, catopril, and some others were in there.
> > I'm not familiar with ondansetron but do remember seeing it mentioned in Dr. Bob's Psychopharmacology Tips -- search perhaps?
> > The key here may be "possible" new ADs; my daughter was in a study that used modafinil as an add-on for the treatment of depression. The consensus of the grumblings [loud] of the study participants was that it did squat.
> > True, this is merely anectdotal. The manufacturer is really pushing this drug for lots of uses. It recently failed in trials for attention deficit disorder, much to the stockholders' dismay.
> > Perhaps the fact that ondansetron is grouped with modafinil should lead us to suspect that it's not going to be very useful?
> > Not a scientific conclusion but perhaps a consumer's surmise.
> > I hope you find something that helps you.
> > S.