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Re: Drug-Induced Weight Gain - Some Mechanisms » Lisabet

Posted by Cam W. on December 7, 2000, at 14:07:48

In reply to Re: Drug-Induced Weight Gain - Some Mechanisms, posted by Lisabet on December 6, 2000, at 18:02:16

> Scott, what is the component/s of Wellbutrin that makes you lose weight? Does it have to do with metabolism?
>
> -Lisa

Lisa - It probably isn't what Wellbutrin has that prevents weight gain, it is probably what it doesn't have. Wellbutrin doesn't block serotonin receptors (5-HT2C, to be exact), histaminergic (H1) receptors or muscarinic/cholinergic (M1) receptors to any appreciable extent. All of these receptors have been implicated in weight gain caused by the tricyclics (TCAs) and SSRIs.

Hope this helps - Cam


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poster:Cam W. thread:50044
URL: http://www.dr-bob.org/babble/20001130/msgs/50142.html