Posted by JackD on December 7, 2000, at 1:29:54
In reply to Re: Any other drugs or combos like Wellbutrin? » JackD, posted by JohnB on December 6, 2000, at 4:17:01
You could very well be right. But, from my literature, and experience, Wellbutrin's method of action has very little to do with it's reuptake of neurotransmitters. It's chemistry is quite complex. If you read back to an older post on this site, you can read an interesting theory. (http://www.dr-bob.org/babble/20000508/msgs/33406.html)
That's just a theory you say? Let me remind you that even the information on Glaxo-Wellcome's page or any other source for that matter is all highly theoretical when it comes to antidepressants.
Also, if you read about several case studies on www.biopsychiatry.com (I know, this site is a little bit eccentric, but their information and references are right on point), you'll see that Wellbutrin only causes significant reuptake of norepinephrine, seratonin, and dopamine at extremely high doses ( >900mg/day). Also, there has been a lot of evidence that suggests that two or more of Wellbutrin's metabolites, and not bupropion itself, is what is responsible for its antidepressant action.
Seratonin reuptake IS inhibited. True, it does not contribute to it's action, but I believe neither are the very mild NE and Dopamine reuptake inhibition.
My purpose was to inform Lynne as accurately as possible about Wellbutrin, and not to let her get her hopes up too high about the suggested combos of stimulants. I think she should not necessarily limit her next antidepressant trial to stimulant combos of NE + Dopamine reuptake.
P.S. John, I'm not here to tell anyone who's right or wrong, I'm just spewing out information for Lynne or anyone reading to absorb and interpret. My information could very well be wrong. But, the more you read about a drug, from all angles and perspectives, the closer you'll come to finding your answer. It is a given that all info be taken with a grain of salt.
poster:JackD
thread:49841
URL: http://www.dr-bob.org/babble/20001130/msgs/50110.html