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Re: Selegiline question, for AndrewB or anybody

Posted by Adam on December 1, 2000, at 12:11:10

In reply to Selegiline question, for AndrewB or anybody, posted by natg on November 30, 2000, at 21:35:47

As a rule of thumb, I think most MDs wait about a month or a little more before switching someone from Prozac to an MAOI. This is because Prozac (well, its active metabolite, norfluoxetine) has such a long half life in the body (upwards of 16 days).

Dangerous interactions with low-dose selegiline and Prozac have been known to occur, though rarely. These cases have been referred to as "serotonin syndrome", though the quality of these diagnoses, depending on what paper you read, may be in doubt. In theory, a 5mg dose shouldn't cause any problems, since only MAO-B ought to be inhibited, and it isn't involved in serotonin deamination. However, in practice, it seems this isn't an airtight assumption.

Given this small but apparently real risk, I would imagine the vast majority of doctors would opt to wait about a month before you could take any dose of selegiline.

If you are somehow treating yourself, be aware of the potential risks, and act accordingly.

> Hi All:
> I want to add 5mg of Selegiline to Risperdal.
> My only concern is can I start immediately or do I need to wait 9 days for the Prozac to be out of my system. I took it for the last time yesterday.
> I'm just concerned because I read that these drugs have severe interactions: increase risk of CNS toxicity and musle rigidity.
> But I'm wondering if this is for higher Selegiline doses ( 10mg and above)
> Anyway, any suggestions would be greatly appreciated.
> Thanks!
>
> Nat


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poster:Adam thread:49725
URL: http://www.dr-bob.org/babble/20001130/msgs/49758.html