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Re: prozac withdrawl-for Ami - Wellbutrin tangent

Posted by SLS on October 31, 2000, at 18:10:36

In reply to Re: prozac withdrawl-for Ami SLS, posted by Sunnely on October 30, 2000, at 20:30:15

Hi guys.

I took Wellbutrin in 1983 as open-label trial in the US. I don't know if that is technically considered a phase III trial, but that is the phase of investigation that Wellbutrin was in at that time.

Sunnely, are open-label administrations of an investigational drug still considered phase III?

Wellbutrin was dispensed as red 150mg tablets. I took two tablets (150mg) three times a day. The investigative physician was Baron Shopsin. He used to send me home with a letter envelope filled with red pills.

During this period of time, the dosage range being targeted by Burroughs Wellcome was between 300mg and 600mg. It was thought that 450mg would be the average effective dosage. Wellbutrin was supposed to be released for marketing later that year. However, a number of studies using bulimics yielded a significant number of seizures. This was probably due to the electrolytic imbalances that can occur in bulimia. The drug company decided not to release it at that point. If I recall correctly, it wasn't until 1990 until it became available.

I am not a good representative of the effects of stimulating or anxiogenic drugs. I sleep just fine taking 15mg of Dexedrine, regardless what time of day I take it. For some reason, Dr. Shopsin liked to tell me about the drugs he was working with. He was perhaps the first one to recognize that there was a reduced liability for Wellbutrin to induce mania. He thought that it might even afford some prophylaxis against mania. The guy really was brilliant. Anyway, he never mentioned a tendency for Wellbutrin to produce adverse reactions at the dosages he was working with. Wellbutrin produces a moderate exacerbation of my depression.

- Scott

> > I took part in one of the phase III investigations of Wellbutrin. I don't know if I was part of one of the dosage-finding type studies, but I had taken 900mg without any adverse reactions and almost no side effects. The only one I can remember was some mild disturbance of visual accomodation.
> >
> >
> > - Scott
> Hi Scott,
> WOW! You must be one of the (few) lucky ones. So, how did you take it? I mean, was it 900 mg once a day, 450 mg twice a day, or 300 mg three times a day? Was the formulation used the "SR"? Did you know you were taking 900 mg per day during the clinical trial? Was this clinical trial done in the US or outside? Just curious.




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