Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Cam or anyone, Anafranil better for OCD? » Trish Baker

Posted by Cam W. on October 31, 2000, at 6:56:22

In reply to Cam or anyone, Anafranil better for OCD?, posted by Trish Baker on October 30, 2000, at 1:23:53

Trish - Anafranil™ (clomipramine) is a TCA with very strong serotonin reuptake (SR) blocking activity relative to it's norepinephrine reuptake (NR) activity. In fact clomipramine is almost a SSRI, except it does have some extra side effects (eg cardiotoxic properties, dry mouth, drowsiness, etc) that SSRIs lack, due to binding to alpha-1 adrenergic an cholinergic/muscarinic receptors (albeit less so than many other TCAs).

Clomipramine is similar to Paxil in binding affinities to SR and NR. Serotonergic antidepressants seem to work well in cases of OCD (as well as panic, social phobia, & PTSD). The problem with SRI drugs in OCD is that they can take a long time to work (eg 26 weeks to see a 50% reduction in obsessions and/or compulsions). Most people give up way too soon (actually, a couple of tears ago, I would probably have said to abandon a drug that seemed marginally work for OCD symptoms, but I have seen more than one person have these delayed results.

In theory Celexa™ (citalopram) should work for OCD, but before combining it with Anafranil, maybe ask your doc about increasing the Celexa dose, first. Ask your doc what he/she feels more comfortable doing.

Relapse of OCD symptoms after stress is common. Perhaps some sort of psychotherapy to deal with the added stress can help the Celexa work better. Again, ask your doc.

Hope this helps - Cam




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:Cam W. thread:47742