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Re: Reboxetine onset of efficacy Q more.....

Posted by JohnL on October 26, 2000, at 16:16:02

In reply to Reboxetine onset of efficacy Q more....., posted by JahL on October 26, 2000, at 13:10:50


> Any thoughts? Anyone?
>
> Thanx in advance,
> ta,
> Jah.

Jah,
My only thought here is that Serzone and Adrafinil kind of cancel each other out, sort of. Though I'm not sure to what degree. That's because one of Serzone's mechanisms is alpha-1 antagonism. Adrafinil is an alpha-1 agonist, just the opposite. I think Adrafinil is more powerful than Serzone at the alpha-1 site and will probably prevail, though perhaps slightly blunted from the Serzone counteracting it a little bit. Just a guess.

I got real depressed with Serzone. I got real good with Adrafinil. I wonder if it had anything to do with their opposite effects at alpha-1.

Reboxetine will probably have additive effects to Adrafinil. Both will potentiate the NE system. So you might find the high dose you want to start with will be too much. It's a possibility to be aware of, that's all.

Even better than Reboxetine though...for the symptoms you described...I would think about Amisulpride instead. I only mention this because Amisulpride+Adrafinil was so effective for me, and my symptoms were exactly like yours. Of course, your mileage may vary. But I personally favor Amisulpride a hundred times better than Reboxetine, especially when combined with Adrafinil. And Serzone for sleep. Sounds good to me.
John


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poster:JohnL thread:47408
URL: http://www.dr-bob.org/babble/20001022/msgs/47441.html