Posted by shellie on October 5, 2000, at 23:27:48
In reply to Re: ketamine drops ------ AndrewB, SLS » shellie, posted by SLS on October 5, 2000, at 8:56:22
Hey Scott, sorry you're sick. I don't have time to answer all your questions now, but I did find the article on medline:
TITLE: Antidepressant effects of ketamine in depressed patients.
AUTHORS:
Berman RM; Cappiello A; Anand A; Oren DA; Heninger GR; Charney DS; Krystal JH
AUTHOR AFFILIATION:
Abraham Ribicoff Center Clinical Neuroscience Research Unit of the Connecticut Mental Health Center, New Haven 06519, USA.
SOURCE: Biol Psychiatry 2000 Feb 15;47(4):351-4
CITATION IDS: PMID: 10686270 UI: 20153964
ABSTRACT:
BACKGROUND: A growing body of preclinical research suggests that brain glutamate systems may be involved in the
pathophysiology of major depression and the mechanism of action of antidepressants. This is the first
placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate
(NMDA) receptor antagonist in patients with depression. METHODS: Seven subjects with major depression completed 2
test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement in
depressive symptoms within 72 hours after ketamine but not placebo infusion (i.e., mean 25-item Hamilton Depression Rating Scale scores decreased by 14 +/- SD 10 points vs. 0 +/- 12 points, treatment).
CONCLUSIONS: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression.Hope you feel better soon,
shellie
p.s., do we need a team uniform?
poster:shellie
thread:45801
URL: http://www.dr-bob.org/babble/20000926/msgs/45851.html