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Re: Anyone heard of Clomipramine , please! » Cam W.

Posted by SLS on September 25, 2000, at 21:19:13

In reply to Re: Anyone heard of Clomipramine , please! » Lisa Simpson, posted by Cam W. on September 24, 2000, at 10:56:44

> Lisa - Clomipramine (Anafranil™) is a tricyclic antidepressant (TCA). All TCAs bind to the serotonin reuptake receptor (like SSRIs, eg Prozac™) and the norepinephrine reuptake receptor (like reboxetine), but their affinities (ability) to bind to these receptors differs. Clomipramine is the TCA that most selectively binds to the serotonin reuptake receptor, very similar to the SSRIs.
> In regard to the SSRIs, I guess you could say that clomipramine closely resembles Paxil™ (paroxetine). Clomipramine does cause more sedation (especially for the first 2 or 3 weeks) and can cause heart problems in overdose. Clomipramine works great in OCD and I have seen some success in panic disorder, as well as being a decent antidepressant.
> Hope this helps - Cam

Hi Cam.

Clomipramine (Anafranil) is a potent SRI but is not selective. It also potently inhibits the reuptake of norepinephrine, as do most of the other tricyclics (trimipramine is the only one I know of that does not). At one time, it was considered to be the most effective marketed antidepressant in the world.

Clorgyline, a reversible selective inhibitor of MAO-A, is the most effective antidepressant in the world. Unfortunately (DAMN IT), it was never marketed and probably won't be. Any ideas on how we can pursuade a drug company to persue it? I don't believe it is patentable.

- Scott




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