Posted by stjames on August 28, 2000, at 19:58:11
In reply to Remeron for SRI Withdrawal? » Sunnely, posted by Jonathan on August 28, 2000, at 18:55:01
An alternative 5HT-3 antagonist that might be less expensive and more accessible than ondansetron (for those whose pdocs will not prescribe meds for off-label uses) is the antidepressant mirtazepine (US Remeron, UK Zispin).
If I'm correct, there may be someone reading this who has switched from Effexor or an SSRI to mirtazepine with no intervening drug-free period and been protected from withdrawal effects by mirtazepine's 5HT-3 antagonism. It's possible, however, that the usual starting dose of 15 mg/day may be too low to block enough 5HT-3 receptors, in which case one would need to escalate quickly to 30 or even 45 mg/day to prevent the previous antidepressant's withdrawal symptoms.
Can anyone out there comment on this from practical experience?Jonathan.
Yes, you would want to go higher than 15 mgs, for my
experience with Remeron.james
poster:stjames
thread:43762
URL: http://www.dr-bob.org/babble/20000822/msgs/43953.html