Posted by JohnL on July 16, 2000, at 9:38:19
In reply to Calling Andrew B (and other babblers), posted by SadSuzie on July 15, 2000, at 16:23:47
> I've been considering trying a combination of amisulpride and adrafinil. However, having read Karen and Kerry's postings on their tremendous success with Zyprexa, I am tempted to approach my psy about the possibility of a trial. Any thoughts on these med combos? What is the difference in Zyprexa and Amisulpride?
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> A quick reminder: I have social phobia, ADD, and atypical depression Tried a multitude of ADs. SSRI’s are a nightmare for me and I've had my "best" results with MAOIs.
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> Your input is greatly appreciated.
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> ss
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> p.s. I’ve had my thyroid thoroughly tested and all results fall right in the middle of the normal ranges.
SadSuzie (but not for long :-)),
I have tried mixing Amisulpride with Adrafinil. I thought it was an awesome combination. And for the diagnosis and symptoms you describe, it could be perfect. Either one alone might be real good, but one added to the other really rounds out the whole thing. So just in case you were wondering if anyone's ever tried it, yes, I have, and it was real good. Tons better than SSRIs or Moclobemide (the only MAOI I've tried) or anything else.I think I may add 25mg or 50mg Amisulpride back into my ongoing Adrafinil. Adrafinil alone is real good, and Amisulpride alone was good too (but not as good as Adrafinil), but the two together are really good. I really liked that combination.
I've tried Zyprexa too. It was one of the best meds I've ever tried. I had two complaints with it that really bothered me, 1)My legs were sore, crampy, and weak all the time; 2)that early morning hangover feeling just got to me. I also gained some weight, which was no big deal since I'm overly skinny anyway. But to someone else that might be a concern. Overall I think Zyprexa is a wonderful med with few side effects for some people, but a couple nuisance side effects for other people. Neither Amisulpride or Adrafinil have affected my weight one way or the other.
Zyprexa does have the advantage of being easier to get. I would guess Zyprexa+Adrafinil could be considered.
Amisulpride is different than Zyprexa in that Amisulpride is more specific in its mechanism of action. It only works on dopamine receptors, and only on very specific dopamine receptors. Zyprexa on the other hand has all kinds of mechanisms on various dopamine receptors, noradrenergic, histaminic, and serotonin receptors. AndrewB is real good at explaining this kind of thing. I'm just generalizing with a wide brush.
I don't know if any of this helps, but I thought I would pass it along.
John
poster:JohnL
thread:40578
URL: http://www.dr-bob.org/babble/20000708/msgs/40629.html