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Re: Cocktail Update:It's Working!! » KarenB

Posted by SLS on July 13, 2000, at 8:03:43

In reply to Cocktail Update:It's Working!!, posted by KarenB on July 12, 2000, at 10:59:48


> It is going on week two and I am feeling much better. Adrafinil (300mg 2x a day) seems to boost mood and motivation as well as provide mild, unwired energy. Adderall helps with focus and energy and at the lower dose I am taking (10mg, 2x a day) has yet to trigger migraines. I stopped taking the Inderal last week and no headaches so far. Hope it stays that way.

I am so excited to hear this. I feel like getting my hands on adrafinil right now and downing a few pills.

I began taking Provigil 200mg/day a few days ago. I experienced an immediate mild improvement that lasted perhaps four hours. For me, this is tremendously significant. Later in the day, I felt pretty dull-witted and kinda zombie-like. This had pretty much worn off by the end of day 2. On day 3, I knew that I still gleaned a small improvement in energy and cognition, but that has begun to dissipate. How does this compare with your experience with Provigil?

That I experienced such a demonstrable improvement over the first two or three days gives me hope that adrafinil might have what it takes. Based on what I have seen here on Psycho-Babble, adrafinil seems to be more effective for depression than Provigil, and produces fewer, if not milder side effects. The only two disadvantages I see for adrafinil is that U.S. citizens must rely upon foreign sources and that it has a liability for stressing the liver. Otherwise, making the decision between Provigil and adrafinil is a no-brainer.

What provisions have you made for monitoring liver function?

What is the nature of the effects on the liver, and what is the rate of their occurrence?

I believe you described experiencing an antidepressant effect with Provigil, even though sedation and fatigue may have been produced by it. I know it will be difficult for you to compare the antidepressant effects of the two drugs given the adverse effects of Provigil, but how would you describe the differences, if any, in the quality and magnitude of improvement? How long did it take for you to see an improvement with both drugs?

Can you make any statements regarding your experiences at 300mg versus 600mg?

To what degree do you think Zyprexa may be acting as an antidepressant? Do you feel that adrafinil is totally responsible for your improvements in depression?

I will try to remain on Provigil for a while longer. I find it very difficult to remain on a drug that has produced a transient antidepressant effect that dissipates. My history has consistently demonstrated that there is no reappearance of a response once it has been lost. I am extremely impatient, especially when I think something better is within arm's reach. I will keep you informed as to how I progress with Provigil, just in case I do well enough to offer you reason enough to try switching at some point in the future.

I would be grateful for any answers you can provide me with.

I am happy for you. I can't help but to smile as I write this. :-)

I wish you continued success.


Sincerely,
Scott

* JohnL - Good work. Applause. Thank you.

 

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