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Andrew: social anxiety meds » AndrewB

Posted by Dwight on June 12, 2000, at 22:11:03

In reply to Dwight: social anxiety meds, posted by AndrewB on June 11, 2000, at 7:15:54


Andrew,

Thanks for all the tips. What you said makes sense. I'll go to the health food store and get some of 7 keto DHEA. I used to take the regular form of DHEA and although it didn't reduce appetite I noticed a definite improvement in muscle tone. I'll give the adrafinil another shot for a longer time period. I didn't know it could take so long to take effect. You have some good tips here. One question: what's the dosage for adrafinil? I'll keep you posted.

Thanks
Dwight


> Dwight,
>
> How to treat social phobia. I have 4 drug suggestions. Remember do only one drug trial at a time so you can be sure what is doing what! By the way, if this seems like a lot of medicines, remember that studies indicate that social anxiety may involve dysregulation of multiple receptor systems (GABA, certain serotonin receptors, D2-D3, and possibly [I haven’t seen a study for this] alpha andrenergic). The side effects should be minimal and all these med.s are relatively inexpensive.
>
> 1) Switch out the neurontin for klonopin. I’ve taken the neurontin. The memory loss is unacceptable . I would think that as a writer you find this side effect troublesome. I have seen two posters on this board say that low dose klonopin lacks cognitive and other side effects when combined with an arousal agent. The latest such post is from Rick. See the post entitled ‘Social Phobia Cocktail, Wow!’ In addition, I remember that one clinic, the Anxiety Network I think, rated klonopin as their #1 social anxiety medicine. They didn’t think much of SSRIs. The one study done on it as a social anxiety med showed it to have, if I remember right, around an 80% effective rate. At low doses, addiction is not a real issue, but withdrawal still needs to be tapered and slow.
>
> 2) Try adrafinil again but before you do try Naphazoline to determine if you respond will respond to adrafinil. For more info. on Naph., see my post entitled ‘For those interested in Adrafinil or Reboxetine’. Remember that adrafinil requires a liver test.
>
> 3) Try your amisulpride. Give it a 15 day trial. If you are like me you will see improvement in less than a week, but some people take longer. It should make you more open, more social, and make you feel less threatened by others. Dwight, where did you order your amisulpride from? Others who would like more info. on amisulpride can email me at andrewb@seanet.com for an information piece I have put together.
>
> 4) Start taking 5 mg. selegiline per day. I don’t know if this will help much but you can give it a try. I believe that the right form of dopaminergic enhancement will increase confidence and boldness (too much will induce mania). I’m currently experimenting with finding such a dopaminergic enhancer. Until I do, deprenyl will have to do.
>
> Below are answers to your other questions.
>
> Amisulpride does not cause weight gain in men. I am told that it is an insignificant problem in women too, but I would like that verified. It does not cause constipation or memory problems. Expect no side effects in men except for sedation. I do not know how common sedation is (for others it has a subtle arousing effect), but I suggest, if sedation occurs without an antidepressant effect, to cut the dosage down.
>
> You can take amisulpride with adderal. Anthony is taking it with ritalin, so it seems to be okay. Adderal and amisulpride both stimulate the striatal D2 receptors. Is this a bad thing or a good thing. I can’t say but personally I have not experienced any (other than transitory) side effects from strong striatal and limbic system D2-D3 stimulation. Overstimulation of other dopamine receptors or receptors in other parts of parts of the brain is more problematic for me.
>
> Adrafinil needs 2 to 3 weeks at its effective dosage to kick in. You can gauge nothing of its effect in a few days. Anything you experience during the first few days on it is in all likelihood transitory. Does adrafinil cause weight gain? No.
>
> Adrafinil does not affect dopamine at all. It does however affect norepinephrine as does adderal. This means that either adrafinil’s or adderal’s dosage would need to be adjusted downward when both are taken together.
>
> In general, I wouldn’t let weight gain be the deciding factor on whether or not you use adderal and how much you use. I understand that weight gain is very important to you but there are other options out there for weight control. I suggest you check out 7-Keto DHEA. A study has shown that at doses of 200mg./day people lose weight on it. Unlike normal DHEA, it has no side effects. I take it myself. The most economical form is the 100mg. capsules.
>
> Does Adderal help you with your ADD and your thinking? What are the symptoms of inattentive ADD. I am interested to know. Does adderal cause any anxiety.
>
> Let me know how it goes,
>
> AndrewB


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