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Re: stubborn moclobemide?! - Z

Posted by SLS on May 25, 2000, at 17:14:50

In reply to stubborn moclobemide?!, posted by z on May 24, 2000, at 13:40:14

> i started taking 300mg/day of moclobemide for social
> phobia about three weeks ago and nothing's happening.
> should my dosage be augmented? should i be patient and
> give the drug more time to work? should i go back to
> paxil (because that worked for me; i only stopped
> taking it because it was making me nauseous)? should
> i add naltrexone to the moclobemide? also, can
> moclobemide help with generalized anxiety? is it as
> effective as paxil for SAD, GAD,panic, OCD, depression?
> -z

> > I've read that if moclobemide is going to work for you it will do so very quickly. It worked for me in 3 days, but (here's the rub) stopped working quite quickly too. Latest ideas are that bigger doses should be given. It didn't have side effects though


> I have taken 600 mg of moclobemide in the past. Nothing much changed with respect to depression and social phobia. It might have helped some what for the first couple of weeks but then the slight effects faded. I had absolutely no side effects which was great. It actually increased my libido (probably associated from moclobemide's effects on dopamine). In the beginning of treatment, I could have up to three orgasms in under five minutes. The increase in my libido turned me into a sex machine and at times, in the middle of the night, I had to run over to my girlfriends house. You see, antidepressant seem to alter my sexual function very much. With effexor I do not even know what sex is while on moclobemide I was a hound dog. Overall, moclobemide was not at all comparible to effexor for my depression and social phobia. Good luck!


> Hey z: Just gotta say I love your handle "z" Very cool. Anyway, I was on moclobemide years ago and it worked really well for my social anxiety and depression. It did take about 6 weeks to work though. I know that's contrary to the above opinions and experience but you know the babble motto "your mileage may vary." I started taking it again in January of this year when my problems returned and were unmanageable. It did not work this time. I don't know if it's stubborn but it sure is finicky. I was on it for almost 3 years but I took 600mgs a day. 300 seems like a low dose to me. I've heard that some people take 900 mgs a day and that works for them. Give it a little time but increasing the dose may help. It didn't cause me any trouble in the side effects dept either. A little nausea for the first week but then it went away. I think with moclobemide, more is better but it's always up to you. Just my experience, hope it helps.---Tina


------------------------------------------------


Hi Z.


All of what has been described above is totally accurate. Dosages as high as 1200mg have been necessary to achieve a sustained response (see stuff written by a guy named Joffe).

For the most part, moclobemide has been a big disappointment for treating depression. The drug company (Roche) tried to get it approved in the U.S. for social phobia. No-go. The first two replies depict the typical scenario seen with moclobemide. The third represents the reason why the drug should probably remain on the market.

Now that you are taking it, I suggest that you try raising the dosage. 450mg - 900mg is the true therapeutic range for this drug.

TINA - from now on... I have pleaded with people on this board to consider the possibility that they will not respond to the same drug once they have discontinued it. If you seem to have a propensity towards relapse, it may be a good idea to stay on the next successful drug regimen for a long time. One thing though, it does occur that one can respond to this same drug at some time in the future. There are cases in which people must switch between different MAOIs to treat their depressions. They switch from Parnate to Nardil to Parnate to Nardil... Perhaps you can recover your response to moclobemide should you fail to respond to other treatments. What's going on with you right now?

Any of the SSRIs are candidates to treat social phobia. It just so happens that Paxil was the first to be awarded this indication by the FDA. Nardil works. I'm not sure if Serzone is effective for social phobia. I think I'll check it out.

I sincerely hope that moclobemide becomes your wonder drug.


- Scott

 

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