Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Mianserin

Posted by SLS on May 20, 2000, at 14:14:14

In reply to AndrewB Re: Magnesium and depression, posted by Sigolene on May 20, 2000, at 3:18:08

Dear Sigolene (are you a boy or a girl?) :-),

I hope you are doing well on mianserin.

Mianserin (Norval) was first released for marketing in the early 1980's. I believe it first appeared in the U.K., but I'm not sure. At the time, some researchers thought it was more effective than the tricyclics. I'm not sure why it was not introduced into the U.S. That it is very sedating and impairs cognitive performance (due to potent blockade of histamine H1 receptors) may have had something to do with it.

Mianserin is chemically related to mirtazapine (Remeron, Zipsin). Like Remeron, it is an antagonist of both norepinephrine and serotonin receptors. It does not inhibit the reuptake of any neurotransmitter at therapeutic dosages. Unlike Remeron, it does not block 5-HT3 receptors. In addition, mianserin does not promote an increase in the levels of serotonin in certain areas as does Remeron. I don't think Remeron is as potent a H1 receptor antagonist as mianserin, and is probably more tolerable with respect to sedating side effects, especially at higher dosages. Both mianserin and Remeron often cause weight gain.

Pharmacodynamics of mianserin (Norval):

NE alpha-2 antagonist
5-HT1c antagonist
5-HT2a antagonist
5-HT2c antagonist
H1 antagonist

- Scott




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:SLS thread:34025