Posted by Adam on May 9, 2000, at 14:50:49
In reply to Re: ZANNAH! ,Re: Remeron/Adam, question??, posted by stjames on May 9, 2000, at 12:54:06
This is just a random link I got off of hotbot:
The relevant text...
Nobel, Organon) is a long-acting tetracyclic compound unrelated to the tricyclic antidepressants. It is a potent antagonist of central pre- and post-synaptic alpha2-adrenergic
receptors and also serotonin (5-HT2 and 5-HT3) and histamine (H1) receptors, and has a moderate effect on peripheral alpha1 adrenergic receptors. Antagonizing histamine
receptors explains its prominent sedative effect, and antagonizing peripheral adrenergic receptors explains its tendency to cause orthostatic hypotension.
I DID however, make a mistake above. Mirtazapine is not an alpha agonist, but an alpha antagonist. I keep getting that one mixed up for
> > Anyway, to answer your question (I hope it's not too late), by
> > "histaminergic" (I must confess I don't remember what post this
> > was) I must have meant that Remeron is, in addition to its
> > other effects
> James here....
> I've taken Remeron for some time and I don't think it works as an antihistamine. I taken allergy tests while on Remeron and I got a good responce to the control, histamine, when it was ingected under the skin.