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Re: Cam Wellbutrin questions

Posted by Rick on April 23, 2000, at 19:54:21

In reply to Re: Cam Wellbutrin questions, posted by Cam W. on April 21, 2000, at 10:18:11

>
> CarolAnn - I take 150mg twice daily since last August (same dosage as the time before). It has worked both times. I think 300mg twice daily is maximum dose (in Canada) unless you are taking other meds that could reduce seizure threshold. Ask you pharmacist about the local rules.
>
> I should also mention that, at around 2 to 3 weeks into the therapy, I turned into a bear. I would lash out for no reason and even look for things to get angry about. This seemed to last about 2 weeks and then went away. I have also heard this happen in others, but they usually stopped the med. It seems you do get over the angriness (sp?). Eat lots of chocolate! - Cam W.

Cam, even though Klonopin has helped sooooo much for my non-depressive social anxiety, I have still (greedily?) been seeking augmentation which might get me to that "home run". I added Celexa about 9 weeks ago. At about week 7 (still at 20 mg) it started filling in some anxiety gaps very nicely. Now while most Celexa side effects were long gone (it actually WORSENED anxiety at first), I was finding my motivation on the low side, and occasional bouts of fatigue which -- at least for me -- worsen social anxiety. So four days ago my pdoc added a low dose of Wellbutrin SR -- 50 mg. Much to my surprise -- given that even BuSpar and selegiline (and those initial weeks of Celexa) made me somewhat more anxious -- I have had NO negative effects from the Wellbutrin, and I'm already feeling more "up" and sociable. Even if the latter is a placebo effect, I'm stil amazed that there has been no downside given my history with other "activating" agents (those doses of BuSpar and selegiline that made me nervous were very low-dose as well).

That's the background, but my question is this: Do Celexa and/or Klonopin lower the seizure threshold? While I'll probably have no need to add much more (if any) Wellbutrin SR, what is a safe maximum in tandem with the other meds? I have no seizure history, although during my short-lived


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