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Re: remeron and anafranil combo?

Posted by JohnL on April 6, 2000, at 2:30:50

In reply to Re: remeron and anafranil combo?, posted by caroline on April 5, 2000, at 14:54:43

> > Caroline,
> >
> > Remeron+Anafranil certainly sounds like a go-ahead combination to me. For most people the combo would be way too sedating. But for you it sounds like it could work very well. The Remeron will stimulate serotonin and norepinephrine, while the Anafranil will inhibit the reuptake of both of them (bias toward serotonin), resulting in an increase of serotonin and norepinephrine activity from two different and distinct modes of action. Try it and see. Remeron has few drug-drug interactions, so I don't see any problem at all other than the possibility of new side effects, which may or may not prove to be bothersome. No way to find out without trying. It does appear safe though, and makes sense based on your past responses to both of these meds.
>
> John, thanks for your prompt reply to my message. Another thought I've had - having read some of the other remeron-related messages on here - is of raising the dose of Remeron (I'm currently on 30mg). Do you have any thoughts on this?

Caroline,

You could certainly try raising the dose. Sometimes the Remeron is less sedating at higher doses, but sometimes it's too sedating. It affects everyone so differently. You would just have to try it and see. What you might do is increase dose perhaps 7.5mg at a time to feel it out. Use a knife to cut the pill into custom sizes.


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