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Re: Effexor + Paxil=TSS?

Posted by medlib on March 11, 2000, at 19:42:21

In reply to Re: Effexor + Paxil, posted by Cam W. on March 11, 2000, at 18:56:27

Cam-
Depending on doses of each, isn't TSS a possibility with this combo? My one brush with that (I took a Paxil not realizing I still had a little Prozac onboard) convinced me that's something I NEVER want to see again!
medlib



> Ray - We probably need to know the dose of Effexor you are presently taking. Unlike the SSRIs (like Paxil) Effexor has linear dose-dependent antidepressant activity. This means that it keeps working better as you increase the dose. The SSRI's activity plateaus after a certain dose (everyone is different). Talk to your doctor and ask about an increase in Effexor dose. I wouldn't do it on you own because the antidepressant activity of Effexor changes at increasing dosages (changes from an SRI to an SRI + NRI and eventually, at very high doses, to a SRI + NRI + DRI). S = serotonin; N = norepinephrine; D = dopamine; and RI = reuptake inhibitor. Also, when incresing the dose, you can temporarily get some of the side effects back that you would have noticed when you started the Effexor. I haven't seen Paxil used in conjunction with Effexor, but maybe someone else in babbleland has. Hope this helps - Cam W.


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