Posted by Cam W. on March 9, 2000, at 11:29:14
In reply to wellbutrin sr max dosages, posted by michael on March 8, 2000, at 1:17:15
Michael - In Canada the maximum dose of Wellbutrin is 300mg/day (150mg twice daily). We only have the SR variety up here. The reason for this is due to the seizure potential. At 300mg daily the rate of seizures is 0.4%, at 450mg it is 1%, and at 600mg it is 4%. The risk is increased if you are taking meds that lower seizure threshold (eg older antipsychotics like Chlorpromazine) and decreased if you are taking drugs that increase seizure threshold (eg anticonvulsant/mood stabilizers like Divalproex). The risk of seizure isn't that great, but I have seen it twice and this was in people taking the older antipsychotics (one was Chlorpromazine-Largactil and the other was Trifluoperazine-Stelazine). I have also seen people take these drugs with Wellbutrin and have no problems, though. - Cam W.