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Re: Scott, Cam, Cindy

Posted by JohnL on February 10, 2000, at 4:27:06

In reply to Re: How Do Prozac & Serzone Work Different?, posted by Scott L. Schofield on February 9, 2000, at 7:22:51

Your vast knowledge of depression and drugs always fascinates me. I look forward to all of your posts. I always learn more and more from you all, as do I'm sure many other people. I'm very appreciative of folks like you who show up regularly to help all of us understand various things a little better.

Concerning NE reuptake of Serzone, that is a confusing issue because different sources of literature say different things. Some don't mention NE reuptake at all. Some say NE reuptake is weak. And some say it is potent. Some say it occurs only in the first few weeks and then dissipates. Who knows. Apparently even the research experts have a hard time helping us out with the facts.

Concerning your question Scott of combining Serzone with an SSRI, I have heard of that being done. Mostly it has been done with Zoloft. Serotonin syndrome risk always exists when multiple serotonin drugs are combined. I think a cautious approach and prudent dosing minimizes or eliminates the risk. I have seen abstracts with the titles stating a dangerous reaction between Serzone and Prozac. Unfortunately the abstract itself was missing. Just the title. No details. I would assume though that the reaction of these two drugs is most likely due to elevation of certain liver enzymes. But it could have been serotonin syndrome. In Dr Bob's Tips I saw a case of uncomfortable anxiety created by combining Serzone and Prozac, which was determined to be caused by a dangerous rise in certain liver enzymes involved in the common metabolism of the drugs. I haven't heard of similar problems with Zoloft. Serzone is sometimes given on an as-needed basis with Zoloft a couple hours before sex. I even heard of one case where a guy was taking 200mg Zoloft and 1000mg Serzone. Holy cow. That guy must have been built like a tank, huh?

In summary though I believe pretty strongly that how any drug works, or doesn't work, for a particular person is determined by many different factors at a molecular level involving the unique chemistry of that person. So to me the fact that literature seems to be in confusion of Serzone NE reuptake, it is nearly irrelevant as I see it. All that matters is that during a personal trial it either works or doesn't work. I wish I could understand all the whys and hows. I don't think I ever will. I'd be happy just to get well. JohnL


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URL: http://www.dr-bob.org/babble/20000209/msgs/20978.html