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Re: Effexor XR and Protriptyline

Posted by Cam W. on January 28, 2000, at 18:21:48

In reply to Re: Effexor XR and Protriptyline, posted by saint james on January 28, 2000, at 16:08:09

> > > I am having some trouble with all day effectiveness on 225 mg. of effexor xr. We have tried several augmentations but none have worked. When i was on Paxil my doc prescribed 5 mg of protriptyline. does anyone know how this same prescript might work with the effexor xr or have any other suggestions?
>
> James here....
>
> Effexor + TCA is a good idea.
>
> j

Teresa - Protripyline has norepineephrine reuptake blocking properties, as well as serotonin reuptake blocking properties, whereas Effexor mainly blocks only serotonin reuptake (it does not have significant norepinephrine reuptake blocking properties as is usually believed according to receptor binding studies). The TCAs, like protriptyline, with their dual action are considered by European psychiatrists to be better antidepressants than SSRIs, like Effexor, but TCAs have more pronounced side effects.

This said, by augmenting Effexor with Protriptyline may give enhanced antidepressant action without causing the increased TCA side effects, because the protriptyline dose can be kept lower than it would be if it was used alone (without Effexor). Give it a try, it may work. Good luck. - Cam W.


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Psycho-Babble Medication | Framed

poster:Cam W. thread:19854
URL: http://www.dr-bob.org/babble/20000128/msgs/19920.html